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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DEF6
All Species:
34.85
Human Site:
Y247
Identified Species:
76.67
UniProt:
Q9H4E7
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H4E7
NP_071330.3
631
73910
Y247
L
Q
P
S
C
L
C
Y
F
G
S
E
E
C
K
Chimpanzee
Pan troglodytes
XP_518424
631
73898
Y247
L
Q
P
S
C
L
C
Y
F
G
S
E
E
C
K
Rhesus Macaque
Macaca mulatta
XP_001116665
631
73997
Y247
L
Q
P
S
C
L
C
Y
F
G
S
E
E
C
K
Dog
Lupus familis
XP_542503
666
77164
Y322
L
K
P
N
I
I
S
Y
Y
V
S
E
D
L
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8C2K1
630
73435
Y247
L
Q
P
S
S
L
C
Y
F
G
S
E
E
C
K
Rat
Rattus norvegicus
XP_228031
630
73547
Y247
L
Q
P
S
C
L
C
Y
F
G
S
E
E
C
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510112
591
69266
Y241
L
K
P
N
I
I
S
Y
Y
V
S
E
D
L
K
Chicken
Gallus gallus
Q5F4B2
586
68393
Y241
L
K
P
N
I
I
S
Y
Y
V
S
E
D
L
K
Frog
Xenopus laevis
Q6PA69
596
70153
Y238
L
K
P
S
S
L
G
Y
Y
L
S
E
E
C
K
Zebra Danio
Brachydanio rerio
Q7SYB5
612
72072
Y242
L
R
P
S
T
L
L
Y
F
T
S
E
D
R
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_790206
454
53839
W223
K
G
H
K
V
T
N
W
K
D
R
W
F
V
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.8
41.4
N.A.
92.5
92.8
N.A.
44.2
44
60.3
67
N.A.
N.A.
N.A.
N.A.
26.9
Protein Similarity:
100
99.6
99.2
60.2
N.A.
95.4
95.8
N.A.
63.8
64.8
77.3
80.5
N.A.
N.A.
N.A.
N.A.
45
P-Site Identity:
100
100
100
40
N.A.
93.3
100
N.A.
40
40
66.6
60
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
100
100
73.3
N.A.
93.3
100
N.A.
73.3
73.3
80
73.3
N.A.
N.A.
N.A.
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
37
0
46
0
0
0
0
0
0
55
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
10
0
0
37
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
91
55
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
55
0
0
0
10
0
0
% F
% Gly:
0
10
0
0
0
0
10
0
0
46
0
0
0
0
0
% G
% His:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
28
28
0
0
0
0
0
0
0
0
0
% I
% Lys:
10
37
0
10
0
0
0
0
10
0
0
0
0
0
91
% K
% Leu:
91
0
0
0
0
64
10
0
0
10
0
0
0
28
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
28
0
0
10
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
91
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
46
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
10
0
0
0
0
0
0
0
0
10
0
0
10
0
% R
% Ser:
0
0
0
64
19
0
28
0
0
0
91
0
0
0
0
% S
% Thr:
0
0
0
0
10
10
0
0
0
10
0
0
0
0
0
% T
% Val:
0
0
0
0
10
0
0
0
0
28
0
0
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
10
0
0
0
10
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
91
37
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _